The international break is over, and several Premier League clubs have had players return with fresh injuries. Manchester United have concerns over Bruno Fernandes, Liverpool have lost both Cody Gakpo and Alexander Isak to injuries sustained on international duty, and Arsenal will probably have to do without Kai Havertz for a while.

Here is the full injury round-up for all 20 clubs, based on the Premier League's official update (last updated on 28 September).

Arsenal

Kai Havertz suffered a hamstring injury on international duty with Germany and is out. Ben White (knock), Cristhian Mosquera (muscle injury) and William Saliba (back) are also struggling. Mikel Arteta is short of options in defence.

Aston Villa

Amadou Onana is out with a cruciate ligament injury, while Marco Bizot, Ian Maatsen, Leon Goretzka and Brian Madjo are also on the injury list.

Bournemouth

Julian Araujo (thigh), Junior Kroupi (foot), Amine Adli (calf) and Veljko Milosavljevic (thigh) are all out.

Brentford

Five players are out: Nathan Collins (calf), Mathias Jensen, Sepp van den Berg (groin), Antoni Milambo (cruciate ligament) and Josh Dasilva (hamstring).

Brighton

Kaoru Mitoma (hamstring), Stefanos Tzimas (knee) and Evan Ferguson (ankle) are out. Mats Wieffer, Femi Azeez and Jack Hinshelwood are doubtful.

Chelsea

Chelsea have five players doubtful with unspecified injuries: Cole Palmer, Reece James, João Pedro, Moisés Caicedo and Marco Palestra. Xabi Alonso has been tight-lipped about the extent of the injuries.

Coventry City

Milan van Ewijk (hamstring), Haji Wright (thigh), Kaine Kesler-Hayden (hamstring), Luke Woolfenden (knee) and Aurele Amenda (calf) are all out for Frank Lampard's side.

Crystal Palace

Takehiro Tomiyasu (calf), Dean Henderson (ankle) and Jean-Philippe Mateta (muscle injury) are out. Chadi Riad is doubtful.

Everton

Christian Nørgaard and Merlin Röhl are both doubtful.

Fulham

Kenny Tete is out with concussion, while Tom Cairney is still struggling with a knee problem.

Hull City

A lengthy injury list: Nobel Mendy (concussion), Charlie Hughes (groin), Eliot Matazo (cruciate ligament), Jack Butland (arm), Oscar Zambrano (thigh), Darko Gyabi (thigh) and Matty Jacob (hips).

Ipswich Town

Jack Taylor is out with a knee injury.

Leeds United

Harry Wilson (thigh), Joe Rodon (hamstring) and Mateo Joseph (knee) are out.

Liverpool

A difficult international break for Liverpool: Cody Gakpo and Alexander Isak both returned with injuries, and Conor Bradley (knee), Hugo Ekitike (Achilles), Vitezslav Jaros (knee) and Giovanni Leoni (cruciate ligament) are out. Federico Chiesa is doubtful.

Manchester City

No injuries to report. Pep Guardiola has his full squad available.

Manchester United

Bruno Fernandes and Patrick Dorgu are doubtful, according to the club's latest update. Marcus Rashford (knock), Benjamin Sesko (knock), Amad (knock), Matthijs de Ligt (back), Manuel Ugarte (knee) and Tom Heaton (hamstring) are out.

Newcastle United

Dan Burn (ankle), Ewan Jaouen (ankle) and William Osula (foot) are out, along with Amar Dedic, Nico Gonzalez and Anthony Elanga (all knocks). Tino Livramento and Joelinton are doubtful.

Nottingham Forest

Nikola Milenkovic (hamstring) and Nicolo Savona (knee) are out.

Sunderland

Brian Brobbey suffered a hamstring injury on international duty and is out alongside Habib Diarra (hamstring) and Romaine Mundle (knee).

Tottenham Hotspur

Mykhailo Mudryk (ankle), Xavi Simons (knee), Wilson Odobert (cruciate ligament) and Dejan Kulusevski (knee) are out. Pedro Porro is doubtful.

This round-up will be updated regularly ahead of the weekend's matches. Check our predicted line-ups for the latest news before kick-off.